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Paroxetine 20 mg weight loss 2x daily to 3x daily, or placebo. In the first phase of study, patients received 1mg/day paroxetine for 2 weeks followed by 2mg/day for 10 weeks. In the later stage of study, patients received 1mg/day paroxetine 20mg for 1 month, followed by 1mg/day for 6 weeks, 1 Where to buy smartburn with hoodia month, and finally 1mg/day for 2 months. The secondary objective of study was to compare the efficacy of SSRI with placebo on weight loss in patients with major depressive disorder. All patients were treated with SSRI or placebo for 8 weeks with a 6-week washout period before the final testing phase. Weight loss was evaluated as absolute and relative weight loss. In the study, patients followed a 6-week active treatment with both SSRI and placebo. At week 8 of treatment, patients were randomized to either SSRI 20mg or placebo. The primary outcome measure was change of baseline weight (before randomization) in terms of absolute and relative weight loss. All procedures including the consenting, monitoring, data collection and analysis of the data were performed according to the Declaration of Helsinki. statistical analysis was performed using SPSS statistical software 16 (release 20.0). A 2-tailed p value <0.05 was considered to indicate statistical significance. Participants were recruited through advertisements in local newspapers, posters, flyers, and by word of mouth. The exclusion criteria were use of oral contraceptives, treatment with benzodiazepines, history of alcohol or drug abuse, pregnancy breastfeeding, and those with severe psychiatric disorders. Exclusionary criteria for SSRI and placebo groups included psychotropic medication use > 8 weeks prior to enrolment and use Online canadian pharmacy discount code of SSRI within the past week ( ). Exclusionary criteria for placebo group included the use of any psychotropic medication > 8 weeks prior to enrolment. Discussion The present study showed that SSRI can partially reduce the relapse rate of major depressive disorder. In particular, both SSRI and placebo group showed a statistically significant improvement in weight loss compared to the baseline level of weight loss and relative loss. The improvement is likely due both to a reduction in appetite and depressed mood. There were several limitations which must be considered in interpreting the results. first limitation is small sample size. The second limitation is that only the first phase of study evaluated the efficacy SSRI treatment. In future studies (up to 5 weeks) it would be a positive step to include these phases of study. Additionally, this study was performed in a short-term study, thus the data from this study will have to be compared with long-term results. Despite these limitations, our results clearly suggest that paroxetine can partially prevent depressive symptoms associated with weight loss. The main findings of this study are consistent with our find